SENSITIVITY OF DIFFUSION WEIGHTED IMAGES IN DETECTION OF SMALL HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CIRRHOSIS LIVER
Keywords:
Hepatocellular, Carcinoma, cirrhosis liver, DWI, MRIAbstract
Objective:To find out the sensitivity of adding diffusion weighted images(DWI) to a standard contrast enhanced MRI
in detection of small hepatocellular carcinoma HCC (? 2cm) in patients with cirrhosis liver.
Material and Methods: The study was conducted at the Radiology Department of Khyber Teaching Hospital, Peshawar
from July 2015 to June 2017. A total of 85 known cirrhotic patients with suspicion of hepatocellular carcinoma on
ultrasound or dynamic contrast enhanced CT scan were included in the study. Patient with known malignancy, hepatic
metastasis or radiological imaging characteristics of benign hepatic lesions (like hemangioma, adenomas and focal
nodular hyperplasia) and patient with pace makers or suffering from claustrophobia were excluded from the study.
Contrast enhanced MRI with diffusion weighted sequences on 1.5 Tesla MR scanner (Achieva, Phillips) were obtained
in all patients.The observations were compared with histopathological findings and follow up imaging.
Results: Diffusion weighted MR imaging was found to be 95% sensitive in lesions measuring 5-20mm in size and
showed 92-93% sensitivity in lesions measuring >21mm in size.
Conclusion: diffusion weighted images (DWI) is non-invasive, fast and accurate method to detect small hepatocellular
carcinoma (HCC) in cirrhosis liver.
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