The EFFICACY OF CIPROFLOXACIN AND CEFOTAXIME IN PATIENTS WITH CIRRHOSIS LIVER PRESENTING WITH SPONTANEOUS BACTERIAL PERITONITIS TO A TERTIARY CARE HOSPITAL

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Zahidullah Khan
Ahmar Rashid
Iqbal Haider
Shams Suleman
Aliena Badshah
Inamullah Khan
Bughdad Khan
Wazir Mohammad Khan
Jamal Ud Din

Abstract

Spontaneous Bacterial Peritonitis (SBP), a known complication of cirrhosis Liver is an acute bacterial infection of the peritoneum. Usually no source of infection is easily identifiable.


Objective:


To compare the efficacy of Ciprofloxacin and Cefotaxime in Cirrhosis Liver patients with SBP.


Material and Methods: This prospective, comparative, single center study was conducted in the Department of Medicine, Khyber Teaching Hospital Peshawar from 1st October 2017 to 31st December 2018. A total of 300 admitted patients having Cirrhosis Liver with SBP were included in this study. The patients were randomized into Group A and Group B. Group A was treated with Intravenous Ciprofloxacin and Group B was treated with Intravenous Cefotaxime given twice daily for a period of 5 days. Diagnostic peritoneal paracentesis was done before the start of the treatment and repeated after 5 days therapy. Patients who were either non cirrhotic or had secondary bacterial peritonitis were excluded from the study.


Results: A total of 300 Cirrhosis Liver patients with SBP were studied in two equal randomized groups. Out of these 168 were male and 132 were female. The mean age of patients in study was 51.14±11.9 years. The age ranged between 15-75 years. In Group A, 82 percent responded to ciprofloxacin and in group B, 86 percent responded to cefotaxime.


Conclusion:


Both intravenous ciprofloxacin and cefotaxime are effective in treating spontaneous bacterial peritonitis in patients with Cirrhosis Liver.


Key Words: Ciprofloxacin, Cefotaxime, Spontaneous bacterial peritonitis, Efficacy.

Article Details

How to Cite
Khan, Z., Rashid, A., Haider, I., Suleman, S., Badshah, A., Khan, I., Khan, B., Khan, W. M., & Din, J. U. (2021). The EFFICACY OF CIPROFLOXACIN AND CEFOTAXIME IN PATIENTS WITH CIRRHOSIS LIVER PRESENTING WITH SPONTANEOUS BACTERIAL PERITONITIS TO A TERTIARY CARE HOSPITAL. Journal of Medical Sciences, 29(02). https://doi.org/10.52764/jms.21.29.2.2
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Articles
Author Biographies

Ahmar Rashid, Classified Medical Specialist Combined Military Hospital BahawalPur Punjab Pakistan

Lieutenant Colonel Classified Medical Specialist

Iqbal Haider, Department of Medicine, Khyber Teaching Hospital Peshawar

Associate Professor Medicine

Shams Suleman, Khyber Girls Medical College Peshawar

Associate Professor

Department of Pharmacology

Khyber Girls Medical College Peshawar

Aliena Badshah, Department of Medicine, Khyber Teaching Hospital Peshawar

Assistant Professor Medicine

Inamullah Khan, Department of Medicine, Khyber Teaching Hospital Peshawar

Associate Professor Medicine

Bughdad Khan, Department of Medicine, Khyber Teaching Hospital Peshawar

Associate Professor Medicine

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