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Objectives: The main objective of this study was to search for predisposing factors for Hepatocellular Carcinoma
(HCC) in North of Pakistan.
Material and Method: This study was conducted in medical units of Khyber Teaching Hospital, Peshawar, from July
2007 to February 2009. A total of 100 patients were selected. The main tools for the diagnosis of HCC were ultrasound
abdomen, CT scan abdomen, serum alpha-feto protein and liver biopsy.
Results: Out of one hundred, 80 patients were males, 72% patients were above the age of 60 years. HCV was present
in 74% of our patents, 13 (13%) patients turned out to be HBsAg positive, in 04 patients both HCV & HBV were
present, while in the rest of 09 (09%) patients no predisposing cause found. Cirrhosis was present in 80% of patients;
the P-Value being 0.538. Serum AFP was raised in 72% of patients.
Conclusion: It is concluded that chronic HCV infection is the commonest cause of HCC.
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