FREQUENCY OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HCV INDUCED LIVER CIRRHOSIS
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Abstract
Objectives: To see how often Hepatitis “C” positive patients culminate in Hepatocellular Carcinoma.
Material and Methods: A case series descriptive study was conducted over a period of more than two years from
January 2010 to February 2012 in Medical “E” Unit of Khyber Teaching Hospital, Peshawar. This included 282
Hepatitis “C” positive patients with cirrhosis of liver. They were of 18 to 65 years of age. These patients were
evaluated for the presence of Hepatocellular Carcinoma by means of ultrasonography, alpha-fetoprotein and
computed tomography of abdomen.
Results: Out of all 282 patients, 35 (12.4%) had single/multiple mass lesion/s in their liver parenchyma on
ultrasonography. Of these 35 patients, 34(97.14%) were labeled to have Hepatocellular Carcinoma, diagnosis
consolidated with the help of Computed Tomography of abdomen and very high levels of Alpha-fetoprotein (AFP).
33 had single mass lesion in liver while 2 had multiple lesions. One (2.86%) out of the total 35 had metastatic liver
disease with normal to slightly raised levels of alpha-fetoprotein.
Conclusion: Hepatitis C has become an epidemic in our country and ending with complications of cirrhosis of liver
and Hepatocellular Carcinoma. It is time to focus our full attention on prevention of HCV infection in the first instance.
Moreover, those patients who have already developed cirrhosis of liver should undergo regular surveillance for an
early detection of HCC so that effective treatment could be instituted in time.
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