URIC ACID IS ASSOCIATED WITH BOTH, XANTHELASMATA AND DYSLIPIDEMIA
Keywords:
xanthelasma palpebrarum, dyslipidemia, uric acid, atherosclerosisAbstract
Objective: To assess the association of uric acid with both, xanthelasma and the fasting blood lipids.
Material and Methods: This cross-sectional study was conducted in the Department of Medicine, Khyber Teaching
Hospital, Peshawar, Pakistan from January 2015 to July 2016 and included 60 cases with xanthelasma palpebrarum
(XP) as the study group, and 60 age and sex matched individuals without xanthelasma palpebrarum (WXP), as the
control group. Each participant had his/her fasting lipid profile determined, along with serum uric acid. The data was
analyzed using SPSS version 16. Independent t-test and Pearson correlation tests were applied.
Results: The values of uric acid, fasting total cholesterol, LDL-C and TGs were higher, and HDL-C lower, in the XP
group, than in WXP group, (P <0.001). Serum uric acid correlated positively with serum total cholesterol, triglycerides
and LDL-C (P <0.001), and negatively with HDL-C, (P < 0.001). Moreover, fasting cholesterol level was higher in XP
group (M=208.32, SD=17.135), than WXP group (M=177.28, SD=8.203), at a statistically significant level of, t (84.69)
=12.65, P <0.001, Cohen’s D=2.31.
Conclusion: Serum uric acid is higher in subjects with xanthelasmata. Moreover, serum uric acid has a positive correlation
with both; LDL-c and TGs, but an inverse relation with HDL-c.
Downloads
Published
How to Cite
Issue
Section
License
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.
