PHARMACOLOGICAL SCREENING OF HYPERICUM OBLONGIFOLIUM FOR ITS ANALGESIC EFFECT IN MICE.
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Abstract
Objective
The present study investigates the anti-nociceptive activity of crude methanol extract of Hypericum oblongifolium.
Methods
In vivo acetic acid induced writhing test was used for anti-nociceptive effects at 10mg, 20 mg and 30 mg/kg body wt. respectively intraperitoneally.
Results:
The extract doses of 10, 20 and 30 mg/kg i.p. revealed significant inhibitory effect (P < 0.001) in acetic acid induced writhing test.
Conclusions:
The methanol extract of medicinal plant Hypericum oblongifolium showed significant analgesic / anti-nociceptive effects in animal models and thus validates the traditional uses of the plant in painful conditions.
Key Words
Hypericum oblongifolium, Methanol extract, Anti-nociceptive activity,
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