VITAMIN B12 DEFICIENCY IN TYPE II DIABETIC PATIENTS ON METFORMIN THERAPY;A STUDY CONDUCTED IN TERTIARY CARE HOSPITAL OF PESHAWAR
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Abstract
Objective: To evaluate the frequency of Vitamin B12 deficiency in local Type II diabetic patients using Metformin.
Materials and Methods: A Cross Sectional study was conducted in the department of General Medicine, Khyber Teaching
Hospital, Peshawar from August, 2016 to January, 2017after designing proper inclusion and exclusion criteria and
getting approval from Ethical and Research committee of hospital. A total of 130 Type II diabetic patients were selected
from OPD with 14.1% proportion of vitamin B12 deficiency, 95% confidence interval & 6% margin of error using WHO
sample size calculator. Those with Vitamin B12 levels less than 100 pg/mL were considered as deficient. Vitamin B12
deficiency was stratified among age, gender and duration of metformin usage to see the effect modifications.
Results: Study showed presence of vitamin B12 deficiency in 19 (14.61%) patients whereas in 111 (85.38%) patients
it was not detected.
Conclusion: Modest prevalence of vitamin B12 deficiency among Type II diabetic patients treated with Metformin was
observed.
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