THE RELATIONSHIP OF DIABETIC CONTROL WITH SERUM ALANINE AMINOTRANSFERASE LEVELS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND TYPE 2 DIABETES MELLITUS (T2DM)

Abstract

ABSTRACT

Objectives

This study is aimed to find out the relation of Diabetic control with serum Alanine aminotransferase in patients with Non Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.

Material and methods

This cross sectional descriptive study was conducted from August to October 2019 in general medical outpatient department of Khyber Teaching Hospital Peshawar, a tertiary care hospital in Khyberpakhtunkhwa, Pakistan. Patients with non Alcohohol Fatty Liver Disease and T2DM were categorized into two groups. Group A with HbA1c from 6.5-8% and group B with HbA1c of more than 8%. Serum Alanine aminotransferase levels were correlated in these groups with the level of HbA1c. Data was collected through a specially designed proforma and was analyzed through statistical package for social sciences, SPSS version 23.

Results

Amongst 452 patients with T2DM, 289 were females and the rest of 163 were males, NAFLD was present in 197 patients. Amongst these 197 patients Serum Alanine aminotransferase was raised in 17 (27.86%) patients in Group A but was raised in 64 (47.05%) patients in Group 2.

Conclusions

Diabetic control was positively correlated with serum Alanine aminotransferase level in our patients with Non Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.

Keywords

Type 2 Diabetes Mellitus, Non Alcoholic Fatty Liver Disease, Serum Alanine Aminotransferase.