GLUCOSE 6 PHOSPHATE DEHYDROGENASE (G6PD)ENZYME DEFICIENCY IN JAUNDICED INFANTS IN KHYBER PAKHTUNKHWA
Keywords:
G6PD deficiency, jaundice, infant, Bilirubin, Oxidative drugsAbstract
Objective: To evaluate the frequency of G6PD deficiency by a G6PD quantitative method in jaundiced infants coming
from different districts of Khyber Pakhtunkhwa.
Material and Method: This was descriptive cross sectional study done in the departments of Pathology, Hayatabad
Medical complex and rehman Medical Institute of Peshawar, from February 2016 to September 2016. 300 (Male n=200,
Female n=100) hyperbilirubinemia infants of < 01 year were randomly selected. Through aseptic technique 4 ml blood
was collected for bilirubin and G6PD enzyme assay. Serum bilirubin was determined by Diazo reaction method using
Architect plus ci8200 (Abbott) and G6PD quantitative enzyme assay was measured by the Ultraviolet kinetic method
(Trinity biotech kit, USA). Data were recorded and analyzed on SPSS-20.
Results: In the present study 33 (11%) jaundiced infants were G6PD deficient and 267 (89%) infants had normal G6PD
level. In male jaundiced neonates 25 (12.5%) were G6PD deficient and 175 (87.5%) with normal level of G6PD. In female
jaundice infants 08 (08%) were G6PD deficient while 92 (92%) had normal G6PD level. No significant differences in the
G6PD enzyme level were seen among male and female jaundiced infants. Mean serum total bilirubin in G6PD deficient
neonates and normal infants was 13.8 mg/dl and 12.2 mg/dl respectively.
Conclusion: The present study revealed that infants presenting with jaundice have a high percentage G6PD deficiency.
As in our region, malaria is endemic and poverty leads to frequent episodes of infection, certain drugs can cause fatal
hemolysis.
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