INHERITED ANTITHROMBIN DEFICIENCY IN PATIENTS WITH RECURRENT THROMBOTIC EVENTS
Keywords:
Heritable, thrombophilia, Natural, anticoagulant deficiency, Deep vein Thrombosis, cerebrovascular accidents, Activated protein CAbstract
Objective: To investigate the frequency of hereditary antithrombin deficiency in patients presenting with recurrent
thrombotic events, venous and/or arterial.
Material and Methods: This is a descriptive case series study, where a total of 145 cases with a history of recurrent
thrombotic attacks, both venous and/or arterial, referred by physicians and gynaecologists of Military Hospitals (MH
and CMH) to Armed Forces Institute of Pathology (AFIP) Rawalpindi and from the tertiary care hospitals of Rawalpindi
and Islamabad, were included in the study, through non-probability convenient sampling. Peripheral blood samples
were collected in trisodium citrate in test tube and centrifuged to obtain plasma, which was, then run in coagulation
analyzer to perform functional assay (both clotting and chromogenic) and the level and activity of the Antithrombin
measured and entered in the data sheet.
Results: Among 145 cases, inherited deficiency (low levels) of antithrombin was detected in nine cases with frequency
of 6.2% and p value of less than 0.001. The frequency detected shows significant association between inherited deficiency
of antithrombin and recurrence of thrombosis.
Conclusion: There is a definite association of hereditary antithrombin deficiency with the recurrence of thrombotic attacks.
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