PATTERN OF HEMATOLOGICAL DISORDERS ON BONE MARROW ASPIRATE EXAMINATION

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Hamida Qureshi
Nazish Farooq
Muhammad Amjid
Sunia Arif
Ihsan Ullah

Abstract

Objectives: To determine the gender, age distribution, and pattern of blood disorders on bone marrow aspirate examination.
Material & Methods: This study was conducted at Bacha Khan Medical College Diagnostic Laboratory, Mardan,
Pakistan from April 2013 to September 2015. All patients referred for bone marrow aspirations were included in this
study. Patients with known history of bleeding disorders were excluded. Patients with inconclusive bone marrow report
were dropped. The demographic variables included gender, age and pattern of the disorder on bone marrow aspirate
examination. Data retrieved was analyzed by calculating percentage and frequencies.
Results: Over a period of 30 months a total of 133 bone-marrow aspirations were performed. Out of these, 17(12.78%)
cases were dropped (diluted marrow), 74 (55.64%) had non-malignant hematological disorders while 40 (30.07%) had
hematological malignancies. Out of all 133 cases, 10 patients had single lineage cytopenia, 37 had bicytopenias while
47 presented with pancytopenia.
Conclusion: Reactive marrow is the most common finding among non-malignant hematological disorders followed
by megaloblastic anemia. Acute leukemia is the most common hematological malignancy. Bone marrow aspiration is
very helpful in ascertaining the cause of the disease.

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