COAGULOPATHIES OF LIVER DISEASES: A NARRATIVE REVIEW
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Abstract
Background: Liver is considered to be one of the synthetic organs regarding coagulation factors. Patients with liver
disease undergo a rebalanced state, where a procoagulant state is also established along with an anticoagulant state.
The risk of thrombosis is as common as the risk of bleeding.
Aims and objectives: The following discussion will highlight the importance of rebalanced system and will explain
the role of common coagulation tests in patient with advanced liver disease. This discussion will also emphasize the
limitation of common coagulation tests and will describe an approach to such patients in clinical settings.
Material and Methods: A narrative literature review utilizing PubMed and OVID as databases was carried out in August
2018. Keywords used were: “Advanced liver disease”, “Coagulation disorders”, “Thrombosis and embolism” and
“Coagulopathy of liver diseases”. This literature search was confined only to studies performed on human beings and
published in English language only.
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