ASSOCIATION OF CLINICOPATHOLOGICAL PROGNOSTIC PARAMETERS WITH HORMONE RECEPTOR STATUS IN BREAST CARCINOMA

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Shahida Tasneem
Naila Ismail
Syed Khanzada Khan
Mah Muneer Khan

Abstract

Objective: To know the frequency of Estrogen, progesterone and HER-2neu receptor immuno expression in breast cancer, its molecular subtypes and association with the clinicopathological parameters.
Material and Methods: A total of 64 specimens of breast cancer were collected at Khyber Medical College in the study period from December 2015 to May 2016. To assess the morphological tumor characteristic,ER, PR & Her 2/neu status, Formalin fixed paraffin embedded sections were stained with Eosin Hemotoxylin and Monoclonal mouse antihuman anti-ER antibodies (code IR657/IS657), anti-PR antibodies (code IR068/IS068), and Her-2/neu by Hercep Test kit. ER, PR was assessed by Allred scoring system and HER-2 by Hercep method. Statistically frequencies and percentages of all the parameters were calculated with SPSS version 20. Association of Clinicopathlogical parameters with hormonal statuswas studiedusing Chi-square test.
Results: In total of 64 cases the mean age of the patient was 44.88 years ±12.22 SD. Among them 73% were premenopausal
patients, including (40%) between 23-35 years. Histologically all were of invasive ductal carcinoma type. The estrogen, progesterone and HER-2 receptor positive cases was 87.5%, 76.6% and 13.4% respectively. Significant association of PR was found only with the premenopausal and postmenopausal status and with skin involvement with the p-values < 0.044 and <0.040 respectively. However no significant correlation was seen with all other parameters. The correlation of ER, PR with HER-2 was also not significant. These cases were categorized as luminal A79.7%, Luminal
B10.9%, HER-2 Positive 1.7% and triple negative 7.8%. There is inverse relationship between expression of ER, PR, and Her-2 neu.
Conclusion: Large number of patients was positive for ER and PR and may show good response to personalized therapy. Further larger analytical studies are required to evaluate the hormonal status of breast cancer and response to targeted therapy. HER-2/neu positive patients were few because of economic issues and lack of facilities, needs consideration on government level to help out the needy patients.

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