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Objective: To compare the efficacy of oral with vaginal progesterone in the treatment of threatened miscarriage in first
Material and Methos: This study was conducted at Department of Obstetrics and Gynaecology, women and children
teaching Hospital Bannu. Duration of the study was one year January 2016 to December 2016. Study design was
randomized controlled trial. In this study 98(49 in each group) patients were observed by women with threatened miscarriage
in their first trimester (up to 12 weeks) and age group 15-45 years were included. All women were subjected
to detailed history and clinical examination. Women were randomly allocated in two groups by lottery method. Women
in Group A was subjected to oral progesterone (10mg twice daily) while women in group B was subjected to vaginal
progesterone (400mg per vaginal for one week). All women were followed till the end of 20th week of pregnancy to
determine the efficacy of either procedure. Efficacy was determined in terms of absence of bleeding per vagina and
pregnancy proceeding beyond 20 weeks of gestation. All information like age, address POG and efficacy were recorded
on pre designed Performa.
Results: Our study shows in oral progesterone group, mean age was 31 years with SD ± 3.88 while in vaginal progesterone
group mean age was 30 years with SD ± 3.12. More over oral progesterone was effective in 90% patients
while vaginal progesterone was effective in 71% patients.
Conclusion: Our study concludes that oral progesterone was more effective than vaginal progesterone in preventing
threatened miscarriages in first trimester.
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