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Objective: To differentiate diffuse Uterine Leiomyomatosis (DUL) from multiple leiomyomas and endometrial stromal sarcoma asit may exhibit a histological overlap thereby posing a diagnostic challenge.
Case Report: We present a 38 year old female withcoexistent diffuse leiomyomatosis as well as intravascular leiomyomatosis of the uterus mascerading as an endometrial stromal tumor. A strong positivity for desmin and progesterone receptor (PR) favored DULwhile negative immunoreactivity for CD-10 helped in excluding endometrial stromal tumor.
Conclusion: DUL is a distinct entity from the uterine leiomyomas in terms of varied gross and microscopic features. To the best of our knowledge, this is the first report of coexistence of two rare variants of leiomyoma- diffuse and intravascular leiomyomatosis.
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