CYTOKINE AND HORMONAL PROFILE IN OSTEOARTHRITIS SUBJECTS

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Sadia Ikhlaque heikh
Hina Abbas
Nighat Mirza

Abstract

Objective: To assess whether the hormones and cytokines are linked with postmenopausal osteoarthritis.
Material and Methods: The study comprised of one hundred and fifty patients suffering from OA and one hundred and
thirty control groups having the age from 44 to 58 years. Thyroid hormones (T3, T4) , calcitonin, estrogen, progesterone
hormones, and Interleukin-6 (IL-6) were analyzed by ELISA
Results: Level of serum estrogen in OA subjects and control subjects were 29.73 ± 4.96 and 51.16 ± 3.11 respectively.
(P<0.0001). This value was significantly low in the patients when compared with controls. Patients also show significant
high interleukin 6 levels (21.98 ± 0.33) when compared with control subjects 5.4 ± 0.1.9 (P < 0.0001).
Conclusion: It is suggested that estrogen deficiency after menopause is associated with osteoarthritis in postmenopausal
women.

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