CLINICAL AND LABORATORY PROFILE OF DENGUE FEVER IN KHYBER TEACHING HOSPITAL, PESHAWAR

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Jamal Uddin
Muhammad Asghar
Amjid Shahzad
ZahidUllah Khan
Noor Rehman
Naveed Sharif

Abstract

Objectives: To find out the frequency of various clinical and laboratory findings in patients with Dengue fever.
Material and Methods:This single center, cross-sectional study was conducted in Department of Medicine Khyber
Teaching Hospital Peshawar from September, 2017 to October, 2017. A total of 3300 admitted patients with suspected
dengue fever were enrolled in study. All patients with fever but dengue negative profile were excluded from study.
Thorough history and physical examination were performed, and blood samples were collected from all dengue positive
patients according to the already designed proforma. Blood samples were analyzed in local hospital library under
supervision of consultant pathologist.
Results: A total of 3300 patients were screened for dengue NS1by Immunochromatographic Technique (ICT) and
confirmed by Enzyme Linked Immuno Sorbent Assay(ELISA). Out of 3300 suspected patients with dengue fever, 612
(18.5%) patients were found positive for NS1 by ICT and ELISA both. Four hundred and eleven were males and 201
were females with male to female ratio as 2:1. The most common clinical findings were high grade fever, headache,
nausea, retro orbital pain and bleeding diathesis. Thrombocytopenia, raised hematocrit levels and raised ALT were the
commonest laboratory abnormalities.
Conclusion: Dengue fever has diverse clinical presentation and laboratory abnormalities.

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