CLINICAL OUTCOME OF DENGUE FEVER AMONG PATIENTS ADMITTED IN TERTIARY CARE HOSPITAL OF PESHAWAR

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Aliena Badshah
Saad Subhan
Wazir Mohammad
Zahidullah Khan

Abstract

Objective: To determine the clinical outcome of dengue fever among patients presenting to tertiary care hospital.
Material and Methods: This study was carried out in Department of Medicine, unit A, Khyber Teaching Hospital Peshawar
- Pakistan from July, 2017 to December, 2017. After taking ethical approval and subsequent informed consent,
a total of 200 patients admitted with dengue fever were recruited in the study using convenience purposive sampling
technique. Patients of either gender, aged between 11 and 80 years were included. A record of blood counts, transfusion
requirements and any complications developed during hospital stay was made from the day of admission till the day
of discharge. The results were analyzed in Microsoft Excel 2017 and tabulated. Frequencies and percentages were
calculated for the categorical variables like gender, age groups, blood counts, dengue serology, NS1 antigen status,
major and minor bleeding diatheses, number of blood transfusions and number of deaths.
Results: Out of 200 patients who were admitted to the medical unit, 136 (68%) were females and 64 (32%) were males.
53 (26.5%) patients were aged between 11-20 years; 60 (30%) patients were aged between 21-30 years; 33 (16.5%)
patients were aged between 31-40 years; 15 (7.5%) patients were aged between 41-50 years; 31 (15.5%) patients were
aged between 51-60 years; 6 (3%) patients were aged between 61-70 years, and 2 (1%) patients were in the age group
of 71-80 years. 111 (55.5%) had positive dengue serology, while 89 (44.5%) had negative serology. All 200 patients had
positive NS1 Antigen status. On admission, 86 (43%) of the patients had platelet counts < 50,000/cm3. At the time of
discharge, only 11 (5.5%) patients had platelet counts < 50,000/cmm.72 (36%) patients experienced minor bleeding
diatheses in the form of nose bleeds, gum bleeding, petechial hemorrhages, blood in saliva etc. Only 2 (1%) patients
developed major bleeding diatheses in the form of per rectal fresh bleeding, hematuria or intra-cranial bleed. Eight (4%)
patients went into dengue shock syndrome, as evident from a blood pressure less than 80/60mmHg. Twenty two (11%)
patients received between 1-3 platelet transfusions; 46 (23%) patients received between 4-6 platelet transfusions, while
3 (1.5%) patients received between 7-9 platelet transfusions.Death was recorded in 2 (1%) patients with dengue fever.
Conclusion: Dengue fever is associated with a relatively good clinical outcomein patients admitted to tertiary care
hospital and is associated with serious complications in only a small subset of patients

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