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Objective: To compare the efficacy of Amoxicillin-Clavulanate and Levofloxacin in the treatment of acute bacterial
rhinosinusitis in terms of complete resolution of signs and symptoms.
Material and Methods: This was a Randomized control study conducted at the ENT Department of Ayub Medical
Institute (AMI), Abbottabad and Khyber Teaching Hospital (KTH), Peshawar from January 2014 to June 2014. A total of
360 patients included in this study were divided in to two groups by non probability technique. Group A included 180
patients who received Amoxicillin-Clavulanate while Group B received levofloxacin for 10 days. Patients were reevaluated
for complete resolution of signs and symptoms on 11th day.
Results: A total of 360 patients were included with a mean age of 31.16 ± 12.51 years. On the 11th day a total of 317
(88.1%) patients had complete resolution of symptoms and signs including 161 (89.44%) of group A and 156 (86.66%)
of group B. There was no statistically significant difference in the frequency of patients and duration of resolution of
signs and symptoms between the two groups.
Conclusion: There was no significant difference in the frequency of patients who had complete resolution of signs
and symptoms between the Amoxicillin-Clavulanate and Levofloxacin receiving patients; hence the two drugs were
similar in efficacy.
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