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Objective: Comparison of efficacy of Misoprostol vs Tranexamic acid in reducing intraoperative blood loss in myomectomy.
Material & Methods: This was a prospective comparative study, conducted in Gynae “B” Unit MTI-Lady Reading
Hospital Peshawar-Pakistan from Jan 2018 to Dec 2018 including fifty cases of fibroid uterus undergoing abdominal
myomectomy. Twenty five cases were given misoprostol while other twenty five received Tranexamic acid preoperatively,
by consecutive sampling. Women included in the study had fibroid uterus size ranging from 6-16 cm. These
were all single intramural fibroids. Women with multiple fibroids, size more than 16 cm and those having submucosal
or subserosal fibroid were excluded.
Results: Fifty women were included in the study who had single intramural fibroid with size ranging from 6-16 cm.
Group A received 400 mcg Misoprostol per vaginal, I hour before surgery, and Group B received intravenous Tranexamic
acid during the course of surgery. Mean age was 28.68 years in both groups. No significant difference was observed
in sosciodemographic data in two groups. Intraoperative blood loss was significantly reduced in Misoprostol group (
P< 0.014) with mean difference of blood loss of 171.092 ml compared to Tranexamic acid. There was no significant
difference concerning the duration of surgery, fall in haemoglobin level and need of blood transfusion.
Conclusion: Good clinical outcome, easy to use and minimal side effects proves Misoprostol to be useful in reducing
blood loss in myomectomy.
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