EXPRESSION OF SURVIVIN IN ORAL MALIGNANCY AND PREMALIGNANCY

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Hoor Maryam
Sabeen Nasir
Mohammad Mumtaz Khan
Abbas Saleem
Nasiha Bashir
Fatima Iqbal
Tehmina Nausheen

Abstract

ABSTRACT: Oral potentially malignant disorders (OPMDs) have the risk of transformation into Oral squamous cell carcinoma (OSCC) therefore some new biomarkers are required to identify OPMDs at high risk of invasive transformation and to assess the aggressiveness of the tumor and disease progression to OSCC.  Survivin inhibits apoptosis of protein (IAP). Survivin has a dual function both in cell cycle promotion and apoptosis inhibition.


Objectives: To  assess  the  immunohistochemical  expression  of  survivin   in OSCC,  OPMDs, and normal oral mucosa.


Materials and methods: This study comprised of 25 already diagnosed cases of OPMDs, 25 cases of OSCC and 25 normal oral mucosa as a control. Immunohistochemical expression of survivin was analyzed.


Results: Immunoreactivity for survivin was found positive in 60% cases of OPMDs and 100%  in OSCC but was absent in normal oral mucosa only one case showed mild staining intensity.


Conclusion: A statistically significant expression of survivin was observed in OPMDs which may indicate the probability of their transformation to OSCC.


Keywords: Oral Potentially Malignant Disorders, Oral Squamous Cell Carcinoma, Survivin, Immunohistochemisrty.

Article Details

How to Cite
Maryam, H., Nasir, S. ., Khan, M. M., Saleem , A., Bashir, N. ., Iqbal, F., & Nausheen, T. . (2022). EXPRESSION OF SURVIVIN IN ORAL MALIGNANCY AND PREMALIGNANCY. Journal of Medical Sciences, 30(01), 14–17. https://doi.org/10.52764/jms.22.30.1.3
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Author Biographies

Hoor Maryam, a:1:{s:5:"en_US";s:84:"Peshawar Dental College (affiliated with Riphah international university Islamabad))";}

lecturer in oral pathology 

 

Sabeen Nasir, Peshawar Medical College (Affiliated with Riphah International University Islamabad).

Associate professor Histopathology at Peshawar medical college

Mohammad Mumtaz Khan, Peshawar Medical College (Affiliated with Riphah International University Islamabad).

Professor in histopathology

Abbas Saleem , Peshawar Dental College (Affiliated with Riphah International University Islamabad).

Associate professor in Oral Pathology

Nasiha Bashir, Peshawar Dental College (Affiliated with Riphah International University Islamabad).

Associate professor in Oral Pathology

Fatima Iqbal, Peshawar Dental College (Affiliated with Riphah International University Islamabad).

Assistant professor in Oral Pathology

Tehmina Nausheen, Peshawar Dental College (Affiliated with Riphah International University Islamabad).

Assistant professor in Oral Pathology

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