A IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA, ORAL EPITHELIAL PRECURSOR LESIONS, AND NORMAL ORAL MUCOSA

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Abbas Saleem Khan
Sajjad Ahmad
Fatima Iqbal
Abdus Saboor
Muhammad Nisar
Tehmina Naushin
Ahmareen Khalid Sheikh
Mohsian Haq
Tariq Ahmad
Basheer Rehman

Abstract

Abstract


Objective: To assess the immunohistochemical expression of p53 in tissue samples of oral squamous cell carcinoma (OSCC), oral epithelial precursor lesions and normal oral mucosa.


Methods: A comparative cross-sectional study was jointly conducted at the Departments of Pathology and Oral and Maxillofacial Surgery of various medical and dental institutes of the country from April 2016 to March 2017. A total of 180 subjects were included in the study. Oral tissue specimens were collected for lab investigations after obtaining written consent from all subjects. TP53 was assessed by means of immunohistochemistry in tissue samples of 60 cases of OSCC, 60 cases of epithelial precursor lesions and normal oral mucosal samples of 60 healthy individuals. Data was recorded, evaluated and analysed by SPSS version 20.


Results: p53 protein expression was noted in 85%  OSCC and 73% oral epithelial precursor lesions. Among healthy individuals ,one subject showed p53 immunoreactivity in normal oral mucosa.


Conclusion: Raised TP53 overexpression in OSCC and oral precursor lesions, compared to normal oral mucosa make it a probable candidate for potential predictive biomarker in oral premalignancy and malignancy.


 

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How to Cite
Khan, A. S., Ahmad, S. ., Iqbal, F., Saboor, A. ., Nisar, M., Naushin, T. ., Khalid Sheikh, A., Haq, M., Ahmad, T. ., & Rehman, B. . (2022). A IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA, ORAL EPITHELIAL PRECURSOR LESIONS, AND NORMAL ORAL MUCOSA. Journal of Medical Sciences, 29(04), 255~260. https://doi.org/10.52764/jms.21.29.4.9
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Author Biographies

Abbas Saleem Khan, Peshawar Dental College, Riphah International University, Pakistan"

Associate Professor and HoD

Oral Pathology

Peshawar Dental College

Sajjad Ahmad, Peshawar Medical College, Riphah International University

Professor and HoD

Department of Pathology 

 

Fatima Iqbal, Peshawar Dental College, Riphah International University, Pakistan

Assistant professor

Department of Oral Pathology

Abdus Saboor, Saidu College of Dentistry

Assistant Professor

Department of Oral Pathology

Muhammad Nisar, Peshawar Dental College, Riphah International University, Pakistan

Lecturer

Department of Oral Pathology

Tehmina Naushin, Peshawar Dental College, Riphah International University, Pakistan

Assistant Professor

Department of Oral Pathology

Ahmareen Khalid Sheikh, Pakistan Institute of Medical Sciences, Islamabad

Consultant Histopathologist and HoD

Department of Pathology

Mohsian Haq, Peshawar Medical College, Riphah International University, Pakistan

Associate Professor

Department of Microbiology

Tariq Ahmad, Khyber College of Dentistry

Assistant Professor

Department of Oral & Maxillofacial Surgery

Basheer Rehman, Khyber College of Dentistry

Associate Professor

Department of Oral & maxillofacial surgery