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Objectives: To determine the frequencies of various types of haemoglobanopathies in southern areas of Khyber Pakhtunkhwa.
Material and Methods: This cross sectional study was conducted in Department of Pathology, Gomal Medical College
from January 2014 to October 2014. Relevant information’s notede on a questionnaire prepared in accordance with
the aims and objectives of the study.
Results: A total of 62 patients underwent Hb electrophoresis in Department of Pathology Gomal Medical Collge, Dera
Ismail Khan. 27(43.5%) were females and 35 males (56.5%). Majority of the patients 37(59.7%) were in the age range 3
month to 5 years. We received patients from age 3 month to 60 years age for knowing types of haemoglobanopathies.
The distribution of patients was 49(79%) patients DI Khan, Tank 10(16%), Lakki Marwat 2(3.2%) and South Wazirstan
1(1.6%). The Haemoglobin of all patient as recorded from the peripheral smear. It was observed that 43(55%) patients
had Hb < 8g/dl and were candidates for blood transfusion. Of the above group 17 had Hb ranging from 2.2 to 5g/dl
(severely anemic). The Distribution of various haemoglobanopathies were; Beta thallassemia major 16(25.8%), Beta
Thalassemia trait 7(11.3%), Sickle cell disease 6(9.7%), Sickle cell trait 2(3.2%), Sickle cell/Beta thalassemia (double
heterozygosity) 2(3.2%) and HbE/ Beta Thalassemia (Double heterozygous 1(1.6%). 28(45.2%) had normal Hb Electrophoresis
Conclusion: Haemoglobanopathies are common in southern areas of Khyber Pakhtunkhwa. Beta thalassemia major
is a major haemoglobanopathy. Sickle cell diseases are also prevalent in this region especially in the Sherani, Baytani
and Ustrana tribes of Dera Ismail Khan.
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