DIARRHOEA IN PREDOMINANT IRRITABLE BOWEL SYNDROME AND CELIAC DISEASE

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Sheema Khan
Bughdad Khan
Salim Iqbal

Abstract

Objective: To find the frequency of celiac’s disease in patients previously treated for Irritable bowel syndrome by histological
examination of lower duodenal biopsy specimens.
Material and Methods: This was a cross sectional study, including fifty patients, conducted at Department of Medicine,
Khyber Teaching Hospital, Peshawar, Pakistan from February 2013 to May 2013. A total of 50 patients were included in
the study with a mean age of 30 years. Oesophagogastrodeudonoscopy was performed and lower deudonal biopsies
were taken, all specimens were sent in formalin for histopathology examination to screen for villous atrophy.
Results: In this study fifty patients previously treated for Irritable bowel syndrome were evaluated with duodenal biopsy
for celiac's Disease. Twelve patients were found to have biopsy changes consistent with celiac’s disease, resulting in
prevalence of 24%.
Conclusion: Celiac’s disease can cause malabsorption and is a pre-cancerous is condition. A high degree of suspician
is required among physicians for early diagnosis of coeliacs disease and prevention of malignancy.

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