THE RELATIONSHIP OF CONSANGUINITY WITH CONGENITAL HEART DISEASE IN CHILDREN
Keywords:
Consanguinity, congenital heart disease, children, echocardiographyAbstract
Objectives: To find the relationship between consanguineous marriage and congenital heart disease in children.
Material and Methods: This case-control study was conducted from October 2018 to January 2020 at inpatient and outpatient settings of department of child health, Khyber teaching hospital Peshawar. Total 346 children were taken and divided into two equal groups. 173 with congenital heart disease and 173 with no cardiac defect on echocardiography. Consecutive non-probability sampling was employed and echocardiographs of the children were collected and analyzed by SPSS 23.
Results: Out of 346 children from birth to 15 years old, 173 had congenital heart disease and 173 had no cardiac defect. 214(61.8%) were male while 132(38.2%) were female. 274(71.1%) were from 0-1 year age group, 66(19.1%) were from 1-5 years, 20(5.8%) from 5-10 years age group and only 14(4%) were from 10-15 years age group. From the total study population, 119(34.39%) had consanguineous parents and had congenital heart disease with the odds of congenital heart disease 1.68 higher in consanguineous marriages compared to non-consanguineous marriages.
Conclusion: The odds of having congenital heart disease is 1.68 higher in children born from consanguineous marriages compared to non-consanguineous marriages.
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