EFFECT OF INSULIN VERSES METFORMIN ON HYPERGLYCEMIA AND DYSLIPIDEMIA IN TYPE-II DIABETIC PATIENTS
Main Article Content
Abstract
Objective: To compare the anti-hyperglycemic and anti-dyslipidemia effects of insulin verses metformin in diabetic
human subjects.
Material and Methods: Total of 240 blood samples were collected (120 from male and female) for all the three groups
i.e. Group-I serve as non-diabetic individuals, Group-II included diabetic patients treated with insulin and Group-III
included diabetic patients treated with metformin. The study period was from January 2018 to September 2018. Fasting-
serum-glucose, lipid profile, triglyceride, AST and ALT analysis were done with serum samples. Body mass index
was also measured for each subject.
Results: A significant weight gain was recorded in metformin treated group than insulin treated group. Insulin showed
more significant anti-hyperglycemic effects than metformin treated group. Insulin therapy showed more significant reduction
for total-cholesterol and very low density-lipoprotein both in male and female groups. For low-density-lipoprotein a
significant reduction and for high-density-lipoprotein a significant increase was found only in male insulin treated group.
Insulin also showed significant increase for alanine aminotransferase, aspartate aminotransferase only in male group.
Conclusion: Insulin showed stronger anti-hyperglycemic, anti-hypercholesterolemia activities than metformin. Insulin
showed more significant improvement in lipid profile.
Article Details
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.