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Objective: To compare the anti-hyperglycemic and anti-dyslipidemia effects of insulin verses metformin in diabetic
Material and Methods: Total of 240 blood samples were collected (120 from male and female) for all the three groups
i.e. Group-I serve as non-diabetic individuals, Group-II included diabetic patients treated with insulin and Group-III
included diabetic patients treated with metformin. The study period was from January 2018 to September 2018. Fasting-
serum-glucose, lipid profile, triglyceride, AST and ALT analysis were done with serum samples. Body mass index
was also measured for each subject.
Results: A significant weight gain was recorded in metformin treated group than insulin treated group. Insulin showed
more significant anti-hyperglycemic effects than metformin treated group. Insulin therapy showed more significant reduction
for total-cholesterol and very low density-lipoprotein both in male and female groups. For low-density-lipoprotein a
significant reduction and for high-density-lipoprotein a significant increase was found only in male insulin treated group.
Insulin also showed significant increase for alanine aminotransferase, aspartate aminotransferase only in male group.
Conclusion: Insulin showed stronger anti-hyperglycemic, anti-hypercholesterolemia activities than metformin. Insulin
showed more significant improvement in lipid profile.
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