FACTORS DETERMINING THE SEVERITY AND POOR OUTCOME OF CRIMEAN CONGO HEAMRHAGGIC FEVER: EXPERIENCE IN TERTIARY CARE HOSPITALS, KHYBER PAKHTOONKHWA

Abstract

Objective: To identify markers of poor prognosis in patients with Crimean Congo hemorrhagic fever (CCHF).
Materials and Methods: One hundred and twelve (112) cases of fever and thrombocytopenia that had been referred
to tertiary care hospitals of Khyber Pakhtunkhwa during July 2017 to July 2018 were studied. Demographic features,
vital signs, clinical and laboratory findings were collected on a pre-designed performa and analyzed by SPSS 21. A
significant P value was set at <0.05.
Results: Fifteen cases of Crimean Congo hemorrhagic fever confirmed by positive Reverse Transcriptase –PCR were
included in this study. Mortality rate was 33.3%. Late presentation to tertiary care hospital, disseminated intravascular
coagulation, luecocytosis and abnormal coagulation profile were associated with high mortality.
Conclusion: Correlation between clinical and biochemical findings with outcomes in Crimean Congo Hemorrhagic
fever can be used as guidance for risk evaluation and treatment advice.