MATERNAL SERUM VISFATIN LEVEL IN PRE-ECLAMPSIA AND LATE PREGNANCY AND ITS EFFECTS ON BIOCHEMICAL PARAMETERS
Keywords:
Pre-eclampsia, Circulating Visfatin, low birth weight, babiesAbstract
Objective: To determines and evaluate the quantitative variations in the circulating visfatin in conditions like pre-eclampsia
and to compare with the normal pregnant subjects.
Material and Methods: This study conducted in three tertiary care hospitals (Hayatabad Medical Complex, Lady Reading
Hospital, Khyber Teaching Hospital, Peshawar) from May 2014 to February 2015. It included a total of 160 pregnant women. 86 comprising of PE and while 74 were normal healthy pregnant women with gestational age of more than 20 weeks. Serum visfatin level was determined by enzyme linked immunoassay whereas lipid profile was determined by enzymatic colorimetric methods. Data was analyzed using SPSS version 19.
Results: Among the pre-eclampsia patients seventy five (46.90%) were suffering from severe pre-eclampsia and 6.90% were with mild pre-eclampsia. Serum visfatin was noted to be 4.81±3.11 and 5.48±2.74 ng/mL and were highly significant
(p<0.000) when compared with controls. Similar trends in results were observed for urinary albumin, serum creatinine and blood urea respectively.
Conclusions: Significant difference in the serum visfatin levels of the pre-eclampsia compared to healthy pregnant women was observed.
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