ETIOLOGICAL SPECTRUM AND ANTIBIOTIC SENSITIVITY IN CHILDREN WITH ACUTE PYOGENIC MENINGITIS
Keywords:
Acute, Pyogenic Meningitis, Cerebrospinal fluid (CSF)Abstract
Objective: To determine the frequency of causative organisms and their sensitivity spectrum in newly diagnosed acute
septic meningitis.
Material and methods: This study was conducted at department of Pediatrics and Child Health, Khyber Teaching
Hospital, Peshawar, Pakistan from June 2017 till December 2017. A cross-sectional descriptive study design was used
and 88 patients presenting with clinical signs and symptoms of acute septic meningitis were selected through non
randomized convenient sampling. Before enrolling the patients informed consent was taken from the attendant.For
every patient a proper record was maintained on a standardized proforma.Detailed history and examinationwas done
with a special emphasis on signs and symptoms suggestive of meningitis were documented. Lumber puncture was
performed under aseptic technique and samples were sent for analysis and culture to the Khyber Medical College
Pathology Department. Where the CSF culture was performed by Bactec Machine using special culture bottle and the
sensitivity pattern was determined against commonly used antibiotics. Patients age less than 15 years with clinical
features suggestive of Acute Septic Meningitis were included in the study while those who have taken IV Antibiotics in
the last 24-48 hours and Patients with TBM or Viral meningitis were excluded.
Results: Out of 88 patients with meningitis 7 (7.9%) patients had positive CSF Culture. 10 patients had staphylococcus
Epidermidis growth which was considered contamination. Out of 7 positive culture 3 (3.4%) patients had MRSA
positive CSF Culture, 2 (2.2%) patients had Staphylococcus Aurius and 1 (1.1%) patients each had Streptococcus
Pneumonie and E.Coli in CSF Culture.
Conclusion: In our study it was found that MRSA is the commonest cause of septic meningitis comprising 3 (3.4%)
patients followed by Staphylococcus Aurius in 2 (2.2%) and 1 (1.1%) patient each had Streptococcus Pneumonie and
E.Coli. Septic meningitis is a serious condition and inappropriate or delay in the management may result in serious
fatal complications therefore aggressive and appropriate antibiotic therapy is vital for better outcome.
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