FREQUENCY OF STEATOSIS IN CHRONIC HEPATITIS C PATIENTS IN KHYBER PAKHTOONKHWA. A CLINICAL AND HISTOLOGICAL STUDY
Keywords:
Steatosis, Body mass index, necroinflammation, chronic hepatitis CAbstract
Objective: To assess steatosis histologically and correlate with body mass index in chronic hepatitis C patients.
Material and Methods: This was a prospective observational study conducted at Gastroenterology ward and
Department of Pathology at Combined Military Hospital, Peshawar from May 2007 to September 2008. A total of 100
adult patients who were HCV-RNA positive fulfilling the pre-requisites for liver biopsy were admitted. Liver biopsy was
performed and analyzed for necroinflammation, fibrosis and steatosis. Steatosis was correlated with BMI by using
Chi Square test. P value of 0.05 was considered as significant.
Results: Fifty-four male and 46 female patients between ages of 13 to 70 years were studied. Forty-nine patients
(49%) were overweight, 16 (16%) were obese. Twenty-nine (29%) patients showed grade I Steatosis, 8(8%) had grade
II and 4 (4%) had grade III Steatosis. Strong correlation was found between Steatosis and BMI (P-value 0.0001). High
BMI is strongly associated with females of >35 years of age, P-value 0.0001.
Conclusion: Steatosis is related to higher BMI and together with necroinflammation results in accelerated disease
process in chronic hepatitis C patients. Steatosis should always be assessed histologically and included in clinical as
well as research analysis
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