CLOZAPINE AND BLOOD DYSCRASIA — A REVIEW
Keywords:
Clozapine, Leucopenia, Neutropenia, Agranulocytosis, Blood dyscrasia, MonitoringAbstract
Objectives: The objective of the study was to assess the Heamatological issues related with the use of Clozapine.
Material and Methods: It was a review of articles based on use of Clozapine in schizophrenic patients. Although
Clozapine can cause other side effects but in this review article, we assessed different issues of Clozapine induced
blood dyscrasia.
Results: Clozapine monitoring has proved to be highly successful in the early detection and has prevented many
fatalities. The research into Clozapine induced blood dyscrasia has been ongoing for the past two decades and
needs to continue to address unanswered questions regarding mechanism of blood dyscrasia and its prevention.
Conclusion: Clozapine can substantially improve the quality of life of patients with schizophrenia by reducing the
presence and severity of symptoms, decreasing the duration of hospitalization.
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