MEDICAL EXPULSIVE THERAPY FOR URETERAL STONES; BEYOND ALPHA BLOCKERS & STEROIDS

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Zia Ud Din Afridi
Abid Haleem
Khawar Kamran
Ijaz Ahmad
Rashed Tanoli
Abdul Rahim Khan

Abstract

Objectives: To Know the Medical Expulsive Therapy for Ureteral Stones; Beyond Alpha Blockers & Steroids.
Material and Methods: This prospective cohort study was carried out to see the effects of adding Serratiopeptidase to
the already established drug therapy, ‘alpha blockers’ in patients with the ureteral stones size from 05mm up to 10mm,
for the medical expulsion therapy. It consisted of a total of 80 patients. There were 63 male patients (78.80%) as compared
to 17 female patients (21.30%). The mean age of the patients was 25.80 ± 06.43 years (Range = 15 to 41 years).
Results: In our study the stones were cleared in a total of 68 patients (Total stone clearance = 85.00%). IVU was carried
out in 12 patients (15%). The stones clearance was achieved in 08 patients (10%) by Extra Corporeal Shock Wave Lithotripsy
(ESWL) and four patient needed surgical intervention (5%). A total of 12 (15%) patients had failed attempt at MET.
Conclusion: Majority of the clinicians accept the effectiveness of the anti inflammatory and analgesic properties of serratio-
peptidase & this role can be exploited in the medical expulsion therapy of the ureteral stones substituting steroids.

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