ASSOCIATION OF NORMAL WEIGHT OBESITY WITH SERUM SURFACTANT PROTEIN - D
Normal Weight Obesity and Surfactant Protein -D
Keywords:
Infections, Normal weight obesity, SP-D, Waist-Hip ratioAbstract
Objectives: Primary objective was to find frequency of normal weight obesity in males and females and to explore its association with the serum Surfactant protein –D. Secondly we assess and compared infection rates among genders
Methodology: Cross sectional study was performed at Dow University of Health Sciences (DUHS), Karachi in 2012 to 2013, after approval from the institutional review Board. It comprised of 120 participants of both gender with age ranging 30-60 years. Subjects were recruited by non probability purposive sampling technique. Waist-hip ratio was calculated from recorded Waist and hip circumferences. SP-D was determined by ELISA. Statistical analysis was performed by SPSS 20.
Results: Of total 120 studied subjects, 68.3% and 31.7% were male and female population respectively. Females have lower SPD than males (152.12 Vs 85.5, p value 0.001) respectively. 26.3% of females and 12.2% of male population have normal weight obesity (p value= 0.05*). Female poses 2.27 times more risk for generalized infection than male population. (OR= 2.27, p value= 0.04*). WHR and SP-D are negatively associated (Beta coefficient (?) of - 3.15, p value = 0.0001*).
Conclusion: Normal weight obesity frequently found in females than males. Females have lower concentration of SP-D levels and high risk of infection.
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