CLINICAL CHARACTERISTICS OF CRIMEAN CONGO HEMAORRHAGIC FEVER: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN KHYBER PAKHTUNKHWA
Keywords:
Crimean Congo Hemorrhagic Fever, Thrombocytopenia, RT-PCRAbstract
Objective: To describe the clinical manifestations and laboratory features of Crimean Congo Hemorrhagic Fever (CCHF).
Material and Methods: The study was conducted at Lady reading Hospital, MTI, Peshawar from July 2017 to July
2018. 112 suspected cases of CCHF were included. There demographics, clinical features and laboratory findings
were recorded on pre-designed proforma. Blood samples were sent to NIH, Islamabad for testing RT-PCR and CCHFV
antigens and anti-CCHFV antibodies. Data was analysed by SPSS version 21.
Results: 15 cases were found to be positive for CCHFV by RT-PCR and CCHFV antigens. Almost fifty percent of the
studied patients were butchers by profession. Fever, headache and petechial hemorrhages/bruises were the most
common presenting complaints. Thrombocytopenia (platelet count less than 150,000) was the most common laboratory
finding followed by deranged liver function tests and abnormal coagulation profile. Overall mortality was 33.3%.
Conclusion: CCHF carries high mortality with limited treatment options. Health authorities should focus on the primordial
and primary prevention of the disease.
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