INFREQUENT ISOLATES ON CULTURE OF CEREBROSPINAL FLUID IN PATIENTS WITH MENINGITIS IN ADULTS
Keywords:
Meningitis, Antibiotics, Resistance, Staphylococcus aureus, Cryptococcus, Linezolid, VancomycinAbstract
Objective: To identify common pathogens causing meningitis, emerging resistance to antibiotics as delay in treatment
may adversely affect outcome.
Material and Methods: It was descriptive observational study which was conducted in the Department of Medicine,
KRL Hospital, Islamabad, Pakistan from January 2014 to December 2016. It enrolled 200 patients with age ranging
from 12 to 90 years in whom meningitis was suspected. Two cerebrospinal fluid (CSF) samples were collected, one
for routine examination while other for culture and sensitivity. Data was analyzed using Statistical package for social
sciences (SPSS) version 20. Frequencies and percentages were taken where required.
Results: Eighteen (9%) patients showed growth of microorganisms. Among culture isolates 17 (8.5%) were bacteria,
1(0.5%) was Cryptococcus. Relatively more cultures were positive in trauma and surgery related patients mainly gram
negative organisms, being sensitive to Tigecycline, Colistin followed by Imipenem/Meropenem. Staphylococcus aureus
was sensitive to Linezolid and Vancomycin. There is increasing resistance to cephalosporin.
Conclusion: Cerebrospinal fluid (CSF) shows low rates of bacterial growth on culture. Emperical therapy may be
tailored according to underlying clinical condition
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