PROTECTIVE ROLE OF CARNITINE AGAINST THE TOXIC EFFECTS OF VALPROIC ACID ON THE SKELETAL MUSCLES IN ALBINO RATS
Keywords:
Volproic acid, carnitine, Skeletal musclesAbstract
Objective: To determine the protective role of carnitine against the Valproic Acid (VPA) induced toxicity in the skeletal muscles of Albino Rats.
Material and Methods: It was an experimental study of concurrent parallel design in albino rats, carried out in the Department of Pathology Khyber Medical College, Peshawar from January 2012 to December 2013. Thirty adults and apparently healthy albino rats were selected. The animals were divided into 5 equal groups i.e. group A (Control-kept on the diet of animal house only), group B treated with therapeutic regimen of VPA), group C (treated with therapeutic regimen of VPA + supplement of Carnitine), group D treated with toxic regimen of VPA ) & group E (treated with toxic regimen of VPA + supplement of Carnitine). Two sections of each biopsy were taken, thus total 60 sections were taken to see the histological findings. All the animals were fed on the routine diet of animal house and then sacrificed after 03 weeks of treatment. The calf muscle of each animal was properly fixed, sectioned, processed, stained with H & E and then seen under the light microscope.
Results: No significant changes were seen in group A & C. Foci of hyalinization were seen in 2 (16.66%) sections of the muscles of group B & E, and in 4(33.33%) of group D.
Conclusion: The results of the present study shows that carnitine plays a significant protective role against the VPA induced myopathies.
Downloads
Published
How to Cite
Issue
Section
License
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.
