THYROID DYSFUNCTION AND ITS EFFECT ON SERUM LIPIDS
Keywords:
Thyroid dysfunction, Lipid profile, Hyperthyroid, Hypothyroid, EuthyroidAbstract
Objectives: To evaluate the incidence of thyroid dysfunction and to investigate the chemical changes in serum lipids
under the influence of thyroid dysfunctions.
Material and Methods: This study was conducted in Pakistan Medical Research Centre (PMRC), Khyber Medical
College, Peshawar, Pakistan from January 2011 to August 2014 . Blood samples and data were collected from patients
attending the Institute of Radioactive Nuclear Medicine (IRNUM) Peshawar, Pakistan. A Total of 600 cases were included
in this study out of which 214 were euthyroid, 195 and 191 were hyperthyroid and hypothyroid respectively.
Results: The study subjects are divided into three groups on the basis of hormonal assay for the three parameters
i.e. thyroid stimulating hormone (TSH), tri-iodo thyronine (T3), tetra-iodo thyronine (T4). The Euthyroid group which
includes healthy individuals serves as control. The level of significance chosen as 0.05 and p-values were calculated.
Conclusion: Thyroid dysfunctions are more prevalent in females, total Cholesterol (TC), Triglyceride (TG) and Low
Density Lipo Protein Cholesterol (LDL-C) levels are positively correlated with hyperthyroidism as well as hypothyroidism,
whereas High Density Lipo Protein Cholesterol (HDL-C) has no significant relation with thyroid dysfunction
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