CORRELATION OF THYROID DYSFUNCTION WITH SERUM LIPID PROFILE AND ANALANINE AMINO TRANSFERASE
Keywords:
Thyroid malfunction, Alanine amino transferase, Lipid profile, Hyperthyroidism, HypothyroidismAbstract
Objectives: The main objective is to study the association between different degrees of thyroid dysfunction with lipids and Analanine Amino Transferase.
Material and Methods: This study was conducted in Pakistan Medical and Research Council (PMRC), Khyber Medical
College, Peshawar, Pakistan from January 2014 to December 2014, Serum Alanine Amino Transferase (ALT) has been determined by the kinetic method recommended by International Federation for Clinical Chemistry (IFCC). The correlation values were calculated between two parameters i.e., Euthyroid, hyperthyroid, and hypothyroid with serum Lipid profile and serum ALT respectively. Serum Total Lipid profile was measured by applying Enzymatic Colorimetric Method. Coefficient of correlation (r) was also calculated using SPSS version 16.00 as a soft ware statistical package.
Results: In hyperthyroidism, the serum alanine amino transferase (ALT) level was elevated to some extent with mean values T3 (6.98 ± 0.367), T4 (34.75 ± 1.640), TSH (0.25 ±0.003) respectively. In hypothyroidism there is a minor increase in the serum ALT with the mean values less than those found in hypothyroidism T3 (3.31+0.128), T4 (10.71+0.637), TSH (31.47+1.628). This study clearly mentions a positive association between thyroid diseases and increased serum ALT concentration.
Conclusions: The comparison of lipid profile and serum ALT in Hyperthyroid disease is suggesting a highly significant
positive relationship with TC, HDL-C and LDL-C except for TG, VLDL-C. Similarly, lipid profile and serum ALT in Hypothyroid disease is suggesting a highly significant positive relationship with all the parameters of lipids studied.
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