BONE PAINS IN MULTI-TRANSFUSED THALASSEMIA SYNDROME PATIENTS
Keywords:
Thalassemia, syndrome, Bone pain, 25-OHD, CalciumAbstract
Objective: To assess bone health and various vital metabolites for optimum bone growth in local thalassemia major
population.
Material and Methods: The study was conducted from June 2014 to December 2014, after approval from Advanced
Studies & Research Board (ASRB) and Ethical Research Committee, KMU. A comprehensive questionnaire was offered
to 141 thalassemia syndrome patients, followed by collection of blood samples. The samples were processed and
analyzed in the laboratories of IBMS KMU, Peshawar.
Results: Mean age of study group patients was 12.62+5.10 years. Our study findings revealed that 76.6% of the patients
experienced persistent bone pain in the last 4 weeks at different body sites. The mean serum 25-OHD concentration
of study patients was 17.48+11.34 ng/dl, while mean serum total Ca level was 8.67+9.1 mg/dl.
Conclusion: There was a high prevalence of bone pain in thalassemia syndrome patients. It was also found that low
vitamin D levels are negatively associated with bone pains. Low calcium levels were also found to have been negatively
correlated to pains in said patients. The presence of such metabolic derangements may be due to the presence of
high serum ferritin levels and poor nutrition intake. It is therefore advised to monitor these vital metabolites regularly
and replenish where needed.
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