CLINICAL AND HAEMATOLOGICAL PRESENTATIONS OF HAEMOGLOBIN E DISORDERS FROM NORTHERN PAKISTAN
Keywords:
HbE, HbEE, HbE/ Thalassemia, Pathans, Northern PakistanAbstract
Objective: To evaluate clinical and haematological findings in any form of HbE disorder in Pathan families from
Northern Pakistan.
Material and Methods: It was a hospital based, prospective observational study, carried out in thalassemic patients,
at Haematology Department, Kuwait Teaching Hospital and Fatimid Foundation, Peshawar, from July 2010 to
December 2011.
Results: During the study period, a total of 13 cases of HbE were detected in 3650 registered thalassemics with an
incidence of 0.35%. 6/13 (46%) cases of compound heterozygous HbE/ ? thalassemia were found, with four of them
behaving as ? Thalassemia Major (BTM) and two as ? Thalassemia Intermedia (TI). 7/13 (54%) cases were
heterozygous HbE, all asymptomatic. No case of homozygous HbEE was detected.
Conclusion: Haemoglobin E disorders are not uncommon in Pathan families from Northern Pakistan and may
behave as BTM or TI.
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