CLINICAL CHARACTERISTICS AND OUTCOME OF THE INFLUENZA (H1N1) PATIENTS ADMITTED TO THE TERTIARY CARE HOSPITAL, PESHAWAR
Keywords:
H1N1, Influenza, Mortality, infection.Abstract
Objective: To evaluate the clinical characteristics and outcome of H1N1 patients admitted to a tertiary care hospital
in Khyber Pakhtunkhwa.
Material and Methods: A prospective observational study was carried out from December 2015 to February 2016 in
Northwest General Hospital & Research Centre Peshawar. Data was collected using a structured format and statistical
analysis was done using SPSS version 16. P-value less than 0.05 was considered statistically significant.
Results: The mean age of patients was (45.23±15.037) years. Average length of hospital stay was 7.85± 11.7 days,
and 50% of them were females. Clinical manifestations included fever, shortness of breath, and dry cough. Hypertension
9 (34.61%), asthma 4 (15.38%) and pregnancy 3(11.53%) were the most common co-morbidities. Real time PCR was
positive in 11(42.31%) patients. Among 26 patients 17(65.4%) survived and 9(34.6%) died. The clinical parameters
between the deaths and survivors were compared, among these parameters: length of hospital stay (p=0.006), oxygen
saturation (p=0.009) and respiratory support in terms of non-invasive ventilation and invasive mechanical ventilation
(p=0.02) were statistically significant.
Conclusion: The present study revealed the serious nature of H1N1 infection with high mortality. This emphasizes the
need for early institution of the antiviral therapy and close monitoring in these patients irrespective of PCR positivity.
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