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Objective: To find out a suitable drug for the management of OLP which could relieve the agony of the patients suffering from this incurable disease.
Material and Methods: In this prospective study two hundred patients were analyzed at tertiary care center. The diagnosis
was made on detailed history and clinical examination and confirmed with histopathological examination. OLP was labeled as idiopathic. The patients were divided in four groups of fifty patients each without control. Every group was treated with different regimens. Responses to treatment, relapses and side effects were determined by comparing scores with baseline Scores.
Results: The combination of intra-lesional injection (40mg/ml) of triamcinolone acetonide (TA) with 0.1% topical flucinolone
acetonide ointment was effective as compared to 0.1% topical tacrolimus and methotraxate (2.5mg/ week).
Conclusion: Corticosteroid remained the mainstay of treatment of OLP and intra-lesional steroids still have important place today.
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