E COLI URINE SUPER BUG AND ITS ANTIBIOTIC SENSITIVITY — A PROSPECTIVE STUDY
Keywords:
Escherichia Coli, Urinary Tract InfectionAbstract
Objectives: To determine the sensitivity patterns of E Coli to various antibiotics by urine culture and sensitivity in
patients with Urinary Tract Infection (UTI), and to recommend the appropriate empirical antibiotics for UTI while
awaiting culture results.
Materials and Methods: This prospective study was conducted in Medical E Unit of Khyber Teaching Hospital,
Peshawar, Pakistan from May 2007 to Oct 2009. A total of 354 urine cultures was performed. Urine culture was done
using conventional microbiological techniques. Biochemical techniques were used to identify the organisms and
antibiotic sensitivity was determined by Kirby Bauer method.
Results: Out of 354 urine cultures, 276 grew E Coli. The gender distribution was 173(62.6%) females as compared to
103(37.31%) males, with age range of 14-70 years. Urine culture of 270 (97.82%) patients was sensitive to Meropenem,
263 (95.28%) to Piperacillin-Tazobactam, 258 (93.49%) to Cefoperazone–Sulbactam, 260 (94.20%) to Imipenem, 257
(93.11%) to Amikacin, 254 (90.57%) to Ceftazidime, 222 (80.43%) to Ceftriaxone, 62 (22.4%) to Co-Amoxiclav, 37
(13.40%) to Pipedemic Acid, 63 (22.8%) to Ciprofloxacin, 85 (30.79%) to Gentamicin and 53 (19.20%) to Cefotaxime.
Conclusion: E Coli resistance against most commonly used antibiotics is on the rise and we recommend using
Amikacin or Cefoperazone-Sulbactam as the initial empirical antibiotic of choice for treating UTI while awaiting
culture results. We do not recommend using Meropenem, Piperacillin-Tazobactam or Imipenem as initial empirical
antibiotic of choice because of the much higher cost as compared to Amikacin or Cefoperazone-Sulbactam.
Downloads
Published
How to Cite
Issue
Section
License
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.
