ASSOCIATION OF PRETREATMENT LIVER HISTOLOGY WITH SERUM ALANINE AMINOTRANSFERASE LEVEL AND BODY MASS INDEX IN HCV-RNA POSITIVE PATIENTS
Keywords:
Alanine aminotransferase, Body Mass Index, Chronic Hepatitis CAbstract
Objective: To assess association of pretreatment liver histology with serum Alanine aminotrasferase (ALT) level and
Body Mass Index (BMI) in HCV positive patients.
Material and Methods: A prospective study conducted at Pathology and Gastroenterology Departments of CMH
Peshawar from June 2007 to December 2008 included 100 adult HCV RNA positive patients. Percutaneous liver
biopsy was performed and analyzed for necroinflammation, fibrosis and steatosis. The observations were recorded
and analyzed by using SPSS 13.
Results: Fifty-four male and 46 female subjects between ages of 13-70 years were included in the study. 66% patients
had ALT levels of 42-89 IU/L, 74.2% had grade II disease, 12.1% grade III disease. 34% patients had ALT levels of >
90 IU/L. 56% had grade II & 38.2% grade III disease. Correlation of ALT with disease grade was significant, P value
0.029. Association of ALT with disease stage was not significant, P value 0.139. Fifty-six percent of obese patients
had elevated serum ALT. Association of BMI with ALT was significant P value 0.034.
Conclusion: Assessment of pretreatment liver histology and its association with ALT & BMI is helpful to determine the
extent of hepatic damage and presence of steatosis.
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