THE EFFCETIVENESS OF TOPICAL DILTIAZEM IN REDUCING INTRAOCULAR PRESSURE
Keywords:
Betamethasone, Glaucoma, Ocular hypertension, Calcium channel blockers, intra occular pressureAbstract
Objective: To see Intraocular Pressure (IOP) lowering potential of topical diltiazem, a calcium channel blocker in glaucomatous rabbits.
Matereial and Methods: Forty healthy rabbits of a local strain weighing 1.50 to 2.00 kilograms were obtained and kept at the animal house of the Department of Pharmacology, Khyber Medical College, Peshawar. The study was conducted from April 2013 to May 2013 on both eyes of conscious rabbits. Three groups of animals were constituted i.e. Group A, B and C. Group A animals, made ocular hypertensive/ glaucomatous by injecting weekly subconjunctival betamethasone
suspension, were administered topical diltiazem. Group B was also made ocular hypertensive and served as the ocular hypertensive control. It received artificial tears for 4 weeks during the entire research period. And group C was used as the normotensive control. It received no treatment during research.
Results: It was found that topical diltiazem led to the reduction in the intraocular pressure very effectively and briskly. Topical diltiazem exerted intraocular pressure lowering effect in a very brief period of time. It was also associated with tremendous animal survivability.
Conclusion: Topical diltiazem can be used as an alternative anti glaucoma particularly to address ocular hypertensive crises drug in future if found safe in human trials.
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