SUCCESSFUL SALVAGE THERAPY WITH CEFTAZIDIME-AVIBACTAM PLUS AZTREONAM FOR PAN-RESISTANT SERRATIA MARCESCENS SEPSIS IN AN INFANT: A CASE REPORT
Keywords:
Serratia Mercescens, infectious diseases, ceftazidime-, avibactum, aztreonam, KarachiAbstract
Invasive infections caused by pan-resistant Gram-negative pathogens pose significant therapeutic challenges in neonatal intensive care units. We report a 35-day-old male infant presenting with severe sepsis, respiratory failure, and apnea. Initial empirical antimicrobials failed. Blood culture isolated Serratia marcescens with pan-resistance to conventional antibiotic classes, including carbapenems, aztreonam, and ceftazidime-avibactam. Following a pediatric infectious diseases consultation, a weight-adjusted combination of intravenous ceftazidime-avibactam and aztreonam was initiated to exploit potential mechanistic synergy. The patient achieved clinical cure and hematologic recovery over a 21-day course without renal toxicity, suggesting a potential salvage option when standard choices are exhausted.
Keywords: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Infant; Sepsis; Serratia marcescens
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Copyright (c) 2026 Muhammad Moin Ashraf, Dr Noor Ul Ain, Dr Fizzah Ehsan
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