THE IMPACT OF TRANEXAMIC ACID ON HEMATOMA AND SEROMA FORMATION IN BREAST CONSERVATION SURGERY
DOI:
https://doi.org/10.52764/jms.26.34.2.6Abstract
Objective: This study was conducted to evaluate the effect of perioperative tranexamic acid on postoperative hematoma and subsequent seroma formation in patients undergoing breast-conserving surgery (BCS).
Methods: This quasi-experimental study was conducted at the Breast Unit, Khyber Teaching Hospital, Peshawar. Sixty-two patients undergoing BCS with axillary dissection were included and equally divided into two groups (n=31 each). In the intervention group, tranexamic acid (TXA) at 1 g, diluted in 100 mL of saline, was administered intravenously at the time of wound closure, whereas no TXA was administered in the control group. Patients were monitored for hematoma formation, seroma, drain output, drainage duration, and other postoperative complications.
Results: Hematoma occurred in 3 patients (9.7%) in the TXA group and 6 patients (19.4%) in the control group. Seroma formation was observed in 1 patient (3.2%) in the TXA group, while 2 patients (6.5%) in the controls. Neither of these differences was statistically significant. The mean drain output was comparable between the two groups (i.e., 92.1 ± 43.5 ml vs. 95.9 ± 40.5 ml; p=0.73). However, drain removal occurred earlier in the TXA group (4.7 days vs. 6.2 days). No thromboembolic events were reported.
Conclusion: Peri-operative Tranexamic Acid appears safe and may reduce postoperative bleeding and shorten drainage duration, although larger randomized trials are needed to strengthen the results of this study.
Keywords: Tranexamic acid, Breast-conserving surgery, Hematoma, Seroma, Drain output, Breast cancer surgery
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Copyright (c) 2026 Anum Wahid, Irum Sabir Ali, Faryal Saeed, Zarka Ahmad, Abeer Jehanzeb, Almas Afridi, Mah Muneer Khan
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