ASSOCIATION OF VITAMIN D DEFICIENCY IN POLYCYSTIC OVARIAN SYNDROME
DOI:
https://doi.org/10.52764/jms.26.34.2.3Abstract
Objective: To determine the association of vitamin D deficiency in patients with polycystic ovarian syndrome (PCOS).
Material & Methods: A case-control study was conducted on forty-eight patients, twenty-four cases and twenty-four controls, at the Department of Obstetrics and Gynecology at Lady Reading Hospital, Peshawar, Pakistan, from June 2024 to November 2024. Vitamin D deficiency was assessed in patients with PCOS and in controls. Pregnant patients and those already diagnosed with vitamin D deficiency were excluded from the study. 25 OH D3 levels were measured in both groups, and patients with vitamin D deficiency were classified as positive if vitamin D levels were < 20 ng/mL. A Chi-square test and Pearson Correlation Coefficient were used to assess the association between the two categories.
Results: The mean age of cases was 29.88±6.58 years, while the mean age of controls was 30.54±6.13 years (P=0.71). The mean BMI of cases was 27.16±2.60 kg/m2, while that of controls was 25.40±2.70 kg/m2; cases had a notably higher BMI than controls (P=0.02). Cases had a higher frequency of vitamin D deficiency (54.2%) than controls (20.8%; p=0.01). The mean vitamin D concentrations were lower in cases than in controls (24.82±8.59 ng/mL vs 29.54±7.91 ng/mL), with a trend toward significance (p=0.054). However, the frequency of vitamin D deficiency was significantly higher in cases than in controls (54.2% vs 20.8%; p=0.017). Vitamin D concentrations were negatively associated with age and BMI in both cases and controls.
Conclusion: Mean vitamin D levels trended lower in PCOS patients; vitamin D deficiency was significantly higher in the PCOS group, and levels were negatively associated with age and BMI in both groups.
Keywords: Vitamin D Deficiency, Obesity, Polycystic ovarian syndrome
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Samina Aliya Sabir , Shahida Sultan
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.
