CLOTRIMAZOLE, FLUCONAZOLE, KETOCONAZOLE AND ITRACONAZOLE SUSCEPTIBILITIES OF CANDIDA SPECIES IN VULVOVAGINITIS
Keywords:
Candida, Albicans, Glabrata, Krusei, Clotrimazole, Fluconazole, Ketoconazole, ItraconazoleAbstract
Objective: To determine the in vitro susceptibility of vaginal Candida species against commonly used azole antifungal agents.
Material and Methods: The isolates were collected and differentiated, which were later on subjected to susceptibility assays. The forty yeast isolates were identified as C.albicans (n=21) C.glabrata (n=13) and C. krusei (n=6). Twenty nine (72.5%) isolates were susceptible to clotrimazole, twelve (30%) to ketoconazole, eleven (27.5%) to fluconazole and ten (25%) to itraconazole.
Results: Overall susceptibility order of test agents was clotrimazole>ketoconazole>fluconazole> itraconazole.
Conclusion: C. albicans was highly susceptible to clotrimazole however C. glabrata showed extreme resistance to almost all test azoles.
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