ANTI-INFLAMMATORY ACTIVITY OF TARAXEROL ACETATE
Keywords:
Taraxerol acetate, Artemisia roxburghiana, Anti-inflammatory, paw edema modelAbstract
Objectives: To investigate the anti- inflammatory effect of Taraxerol acetate, a pentacyclic triterpene isolated from the
aerial parts of Artemisia roxburghiana.
Material and Methods: The plant materials were shade dried and ground into powder which was extracted 3 times
by soaking with 24 L of methanol for two weeks. Preliminary fractionation of the crude extract, obtained from combine
extract, was done by using solvents of increasing polarity: hexane, chloroform, ethyl acetate and n-butanol. The ethyl
acetate fraction was subjected to silica gel column chromatography with hexane to yield taraxerol acetate. The structure
of isolated compound was confirmed by comparing their corresponding NMR and mass spectral data with those
previously reported. Carregeneen induced paw edema model was used to carry out the anti- inflammatory activity of
Taraxerol acetate in Wistar adult rats.
Results: TA significantly (P< 0.05) reduced the edema induced by carrageenan at a dose of 60 mg/Kg body weight
when measured both at 3h and 5h.
Conclusion: Taraxerol acetate has a significant anti-inflammatory effect in addition to its gastroprotective effect making
it a safer anti-inflammatory agent.
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